C2: Fear acquisition and extinction learning and transition to psychosis

In project C2 we aim to identify aberrancies in fear acquisition and extinction associated with psychotic liability. We will focus on participants with clinical high risk of psychosis and use an established differential fear conditioning paradigm in close collaboration with projects A1 and C1 and a novel fear conditioning paradigm, in which the unconditioned stimulus is aversive imagery. We will also test whether altered psychophysiological and neural (EEG) indicators of fear learning can be accounted for by baseline-differences in neurocognition, arousal and psycho-social vulnerability and whether they predict transition to DSM-5 psychotic disorder by a 72-month follow-up.